Analysis of Kinetic Isotope Effects in Enzymatic Carbon–Hydrogen Cleavage Reactions
نویسندگان
چکیده
منابع مشابه
Enzymatic single-molecule kinetic isotope effects.
Ensemble-based measurements of kinetic isotope effects (KIEs) have advanced physical understanding of enzyme-catalyzed reactions, but controversies remain. KIEs are used as reporters of rate-limiting H-transfer steps, quantum mechanical tunnelling, dynamics and multiple reactive states. Single molecule (SM) enzymatic KIEs could provide new information on the physical basis of enzyme catalysis. ...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2011
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp2022117